Rejuvenex Inj. is an injectable medication that stimulates the immune system to promote wound healing. It contains Polydeoxyribonucleotide Sodium (PDRN), a substance primarily extracted from the semen of salmon or trout. PDRN enhances the expression of growth factors such as VEGF and angiopoietin-1, accelerating tissue repair.

Recent studies suggest that it also promotes new bone formation, contributing to bone regeneration and reducing healing time. When used in dental implant placement or bone grafting cases, it supports the regeneration of gum tissue and alveolar bone, helping to shorten the recovery period.

Moreover, Rejuvenex has shown healing effects in conditions like peri-implantitis (bone loss around implants) and periodontitis (bone loss around teeth), making it a popular choice not only for implant procedures but also for preventive dental treatments in clinics specializing in implantology.

Pharmaceutical Product Information by Korean Ministry of Food and Drug Safety (MFDS)

Ingredients / Content

Each ampoule (3 mL) contains 5.625 mg of Polydeoxyribonucleotide Sodium.

Appearance

A sterile, transparent, and colorless solution presented in a clear glass ampoule.

Korean Ministry of Food and Drug Safety (MFDS) classifies

Other Pharmaceuticals for Functional Use in Tissue and Cellular Applications (Code 490)

Therapeutic Class (KPIC)

Skin and Subcutaneous Tissue Disorders > Wound and Ulcer Treatments > Others

Unit of Packaging (MFDS classification)

Box containing 5 ampoules of 3 mL

Storage

Store in a well-closed container at room temperature between 1°C and 30°C.

Indications and Usage

For the treatment of wounds and tissue repair following skin graft procedures.

Dosage and Administration

The recommended dosage is one ampoule (3 mL) per day, administered by intramuscular or subcutaneous injection.

Precautions for Use

1. Warning
   When opening ampoule injections, glass fragments may contaminate the solution and cause adverse effects. Therefore, ampoules should be opened carefully to minimize the risk of glass particle contamination. Special caution should be exercised when administering to children or the elderly.
2. Contraindications
   Do not administer to patients with known hypersensitivity to the active ingredient or any of the excipients contained in this product.
3. General Precautions
   If hypersensitivity reactions occur following administration, discontinue use immediately and provide appropriate medical treatment.
4. Drug Interactions
   No studies have been conducted regarding interactions between this drug and other medications.
5. Post-Marketing Surveillance in Korea
   A re-examination study conducted over six years in Korea involving 609 patients reported an adverse event incidence rate of 0.99% (6 out of 609 patients, 7 cases in total), regardless of causality. Reported events included pruritic rash, oropharyngeal pain, vomiting, leukopenia, abdominal pain, diarrhea, and nausea—each reported once. No serious or unexpected adverse events were observed.

※ Re-examination Safety Evaluation Summary
An integrated analysis of domestic re-examination data and spontaneous adverse event reports for this drug, compared with adverse event data from all other approved pharmaceuticals in Korea at the time of re-evaluation, revealed no statistically significant increase in adverse event reporting for this product.

Therapeutic Benefits of Rejuvenex:

1. Applicable to conditions requiring tissue regeneration
2. Treatment of chronic ulcers
3. Nourishment for wounds and skin
4. Anti-inflammatory effects
5. Promotion of wound healing

FAQs

What is Rejuvenex injection?

Also known as a DNA injection, PDRN injection, or salmon injection, Rejuvenex is formulated with a DNA fragment as its main ingredient. When administered into the body, it activates anti-inflammatory and tissue regeneration effects specifically at sites of tissue damage.

Can Rejuvenex injection be used in combination with other medications such as steroids or lidocaine?

Currently, no specific drug interactions with other medications have been reported, and it is generally considered safe to use in combination with steroids, lidocaine, and similar drugs.

Can the remaining medication be reused after treatment?

Some people either reuse or discard leftover ampoules, but Rejuvenex injection is more effective when used in sufficient amounts, and it is recommended to use the entire ampoule. In most cases where the medication was ineffective, it was due to dividing and using partial doses.